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July 28, 2014
By: List Labs
By: Suzanne Canada, Ph.D.
Tanager Medical Writing
The world of microbial pathology is often understood as a system of various organisms who are trying to survive by using plants or animals as “hosts”. The dynamics of these systems can described the pathogen as trying to establish a living space for itself, while the “host” does its best to evict these unwelcome tenants. One of the most commonly known pathogens is Staphylococcus, a highly adaptable and ubiquitous opportunistic pathogen. The staphylococcal enterotoxins are small heat-stable proteins used by Staphylococcus strains to help them in their attempt to colonize.
One of the most notable and yet poorly understood properties of Staphylococcal enterotoxin B (SEB) is its potent ability to stimulate immune T-cell proliferation. It doesn’t make sense that a bacterium that is intent on colonization would find it advantageous to promote an immune response. On the other hand, it could have been coincidence or selective adaptation that the mammalian immune system learned to recognize one of its most ubiquitous enemies. After many of years of observation by immunologists that lymphocytes proliferated when enterotoxin was added to whole blood in test tubes, John Kappler dubbed them superantigens (Kappler, 1989).
The following references use SEB as a control for stimulate T-cells:
Use our handy citations finder to search for our Staphylococcal toxins used in research.
The significance of T-cell stimulation by SEB has been the topic of much hypothesis and discussion. The site of SEB binding to T-cells has been investigated to a molecular level (Li, 1998; Saline, 2010). SEB and other enterotoxins are used in investigations of innate immunity to bacterial infections, signaling by toll-like receptors, and the modulation of inflammatory responses, especially cytokine stimulation (Kumar, 2010; Ortega, 2010; Vidlak, 2011; Edwards, 2012). The function, origin, and role in adaptation that t-cell stimulation serves will be a topic of ongoing scientific debate. In any case it is clear that SEB and other bacterial superantigens are very good at bypassing the antigen recognition by T-cells (Sundberg, 2002; Kumar, 2013). Some investigation into the biochemical level of SEB recognition by T-cells has indicated that this protein shares antigenic sequences with known self-antigens in mammals (White, 1989). This observation supports the theory that activation of T-cells plays a role in noninfectious diseases like autoimmune responses (Edwards, 1996; Kumar, 1997; Li, 1996; Sundberg, 2002), which might make SEB an appropriate stimulator when studying these mechanisms of disease. List Labs provides for SEB produced in a native Staphylococcus aureus, for research purposes that provides potent stimulation of the immune system and cytokine production.
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