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#149A (0.25 mg)
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#151 (0.5 mg)
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Diphtheria toxin (DT) is synthesized by certain strains of Corynebacterium diphtheriae and secreted as an inactive proenzyme, composed of a single polypeptide chain having an approximate molecular weight of 58 kDa. DT enzymatic activity is expressed when the proenzyme is nicked into two fragments, A and B, linked by a disulfide bond, then reduced with thiols releasing the N-terminal A fragment (molecular weight 21 kDa). The C-terminal B fragment (molecular weight 37 kDa) has no apparent enzymatic activity but is required for toxicity. Evidence suggests that the B fragment is responsible for recognizing and binding the toxin to cell surface receptors.
Diphtheria toxin catalyzes the ADP-ribosylation of eukaryotic aminoacyl-transferase II (EF-2) using NAD as a substrate, the basis for its toxicity toward eukaryotic organisms. Diphtheria toxin receptor (DTR) is a cell-surface expressed heparin-binding epidermal growth factor-like growth factor precursor (HB-EGF). In monkey cells, another membrane protein, CD-9 increases the affinity of diphtheria toxin for HB-EGF, indicating that two proteins may function together as a receptor.
Sensitivity of mammalian cell lines to diphtheria toxin varies with the presence of receptors. Monkey Vero cells are highly sensitive, hamster cells moderately sensitive, whereas rat and mouse cells without receptors are resistant. An injection of DT has relatively minor effects on normal mice and is used to selectively and transiently deplete the population of specific types of immune cells genetically attached with simian or human DTR. Use of DT in this way allows the normal development of the immune system followed by the selective elimination of specific cells. These studies allow conclusions about the function of the modified cells in various processes.
Diphtheria toxin preparations from C. diphtheriae Park Williams strain 8, are highly purified and unnicked. When followed by trypsin treatment and reduction with dithiothreitol, DT from List exhibits high specific activity. Diphtheria toxin is active on CHO19 or Vero20 cells when diluted to a nanogram or less per milliliter.
Diphtheria toxin CRM Mutant (CRM 197) is a non-toxic, cross reactive DT mutant containing a lesion in the A chain blocking ADP-ribosylation. CRM results from a single base change in the structural gene resulting in the substitution of glutamic acid for glycine. While CRM shows no enzymatic activity, it is immunologically indistinguishable from diphtheria toxin.
In its applications, CRM 197 is similar to diphtheria toxoid. CRM has the advantage of being a well-defined protein in contrast to formaldehyde treated toxin (toxoid) which is non-specifically cross linked and subject to rearrangement. CRM functions as a carrier for polysaccharides and haptens, making them immunogenic.
Diphtheria toxin CRM Mutant preparations from C. diphtheriae are highly purified and migrate as a single major 58 kDa band when examined on SDS-PAGE.
Diphtheria toxoid (DTd) is prepared by formaldehyde inactivation of purified diphtheria toxin. Inactivated bacterial toxins, including DTd, are widely used as protein carriers chemically conjugated to oligosaccarides in licensed vaccines, which induce a more robust immune response against the carbohydrate.
Cell Reports
Hildreth, AD;Padilla, ET;Tafti, RY;Legala, AR;O'Sullivan, TE;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal Of Neuroinflammation
Wang, Y;Sadike, D;Huang, B;Li, P;Wu, Q;Jiang, N;Fang, Y;Song, G;Xu, L;Wang, W;Xie, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Biorxiv : The Preprint Server For Biology
Shin, DS;Ratnapriya, S;Cashin, CN;Kuhn, LF;Rahimi, RA;Anthony, RM;Moon, JJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Hearing Research
Berlingeri, ANC;Pujol, R;Cox, BC;Stone, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Science Immunology
Whitley, SK;Li, M;Kashem, SW;Hirai, T;Igyártó, BZ;Knizner, K;Ho, J;Ferris, LK;Weaver, CT;Cua, DJ;McGeachy, MJ;Kaplan, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Molecular and Cellular Neurosciences
Wang, Y;Wu, Q;Fang, Y;Song, G;Xu, L;Wang, W;Pan, D;Xie, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Communications
Kim, HJ;Park, JH;Kim, HC;Kim, CW;Kang, I;Lee, HK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Bi, Q;Wang, C;Cheng, G;Chen, N;Wei, B;Liu, X;Li, L;Lu, C;He, J;Weng, Y;Yin, C;Lin, Y;Wan, S;Zhao, L;Xu, J;Wang, Y;Gu, Y;Shen, XZ;Shi, P;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Microbiology Spectrum
Thomas, A;Slifka, AM;Hendrickson, SM;Amanna, IJ;Slifka, MK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
van der Veeken, J;Campbell, C;Pritykin, Y;Schizas, M;Verter, J;Hu, W;Wang, ZM;Matheis, F;Mucida, D;Charbonnier, LM;Chatila, TA;Rudensky, AY;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cancer Immunology Research
You, R;Artichoker, J;Ray, A;Gonzalez Velozo, H;Rock, DA;Conner, KP;Krummel, MF;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature
Badrinath, S;Dellacherie, MO;Li, A;Zheng, S;Zhang, X;Sobral, M;Pyrdol, JW;Smith, KL;Lu, Y;Haag, S;Ijaz, H;Connor-Stroud, F;Kaisho, T;Dranoff, G;Yuan, GC;Mooney, DJ;Wucherpfennig, KW;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nucleic Acids Research
Liang, Y;Xie, J;Zhang, Q;Wang, X;Gou, S;Lin, L;Chen, T;Ge, W;Zhuang, Z;Lian, M;Chen, F;Li, N;Ouyang, Z;Lai, C;Liu, X;Li, L;Ye, Y;Wu, H;Wang, K;Lai, L;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Diabetes, Obesity & Metabolism
Jiang, Y;Chen, A;Kline, D;Liu, Q;Ma, J;Wang, Y;Zhang, T;Qian, J;Nelson, L;Prasadan, K;Hu, B;Gittes, GK;Xiao, X;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Mucosal Immunology
Jia, L;Wu, G;Alonso, S;Zhao, C;Lemenze, A;Lam, YY;Zhao, L;Edelblum, KL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Wu, D;Chen, Y;Li, Z;Xie, H;Wang, S;Lu, Y;Bao, L;Zhang, X;Li, C;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
iScience
Sauter, M;Sauter, R;Nording, H;Lin, C;Olbrich, M;Autenrieth, S;Gleissner, C;Thunemann, M;Otero, N;Lutgens, E;Aherrahrou, Z;Wolf, D;Zender, L;Meuth, S;Feil, R;Langer, H;
Product: Diphtheria Toxin CRM197, Mutant
Neuromethods
Stone, J;Rubel, E;Warchol, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Science Immunology
Tatsumi, N;Codrington, AL;El-Fenej, J;Phondge, V;Kumamoto, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal Of The American Heart Association
Yu, HH;Ma, XT;Ma, X;Chen, M;Chu, YH;Wu, LJ;Wang, W;Qin, C;Tian, DS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Disease Models & Mechanisms
Robles-Oteiza, C;Ayeni, D;Levy, S;Homer, RJ;Kaech, SM;Politi, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Immunology
Hu, W;Wang, ZM;Feng, Y;Schizas, M;Hoyos, BE;van der Veeken, J;Verter, JG;Bou-Puerto, R;Rudensky, AY;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Communications
Izumi, G;Nakano, H;Nakano, K;Whitehead, GS;Grimm, SA;Fessler, MB;Karmaus, PW;Cook, DN;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Hearing Research
Xia, M;Wu, M;Zhao, L;Ma, J;Li, W;Li, H;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
González-Garrido, A;Pujol, R;Ramírez, OL;Finkbeiner, C;Eatock, RA;Stone, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature
Casanova-Acebes, M;Dalla, E;Leader, AM;LeBerichel, J;Nikolic, J;Morales, BM;Brown, M;Chang, C;Troncoso, L;Chen, ST;Sastre-Perona, A;Park, MD;Tabachnikova, A;Dhainaut, M;Hamon, P;Maier, B;Sawai, CM;Agulló-Pascual, E;Schober, M;Brown, BD;Reizis, B;Marron, T;Kenigsberg, E;Moussion, C;Benaroch, P;Aguirre-Ghiso, JA;Merad, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Communications
Han, Y;Xia, G;Srisai, D;Meng, F;He, Y;Ran, Y;He, Y;Farias, M;Hoang, G;Tóth, I;Dietrich, MO;Chen, MH;Xu, Y;Wu, Q;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Research Square
Cornejo, M;Denis, R;Romero, G;Fernandez, G;Reynaldo, M;Luquet, S;Perello, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal For Immunotherapy Of Cancer
Kim, BS;Kuen, DS;Koh, CH;Kim, HD;Chang, SH;Kim, S;Jeon, YK;Park, YJ;Choi, G;Kim, J;Kang, KW;Kim, HY;Kang, SJ;Hwang, S;Shin, EC;Kang, CY;Dong, C;Chung, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Vaccines
Komla, E;Torres, OB;Jalah, R;Sulima, A;Beck, Z;Alving, CR;Jacobson, AE;Rice, KC;Matyas, GR;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Scientific Reports
Phong, BL;D'Souza, SJ;Baudier, RL;Wu, E;Immethun, VE;Bauer, DL;McLachlan, JB;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Vaccine
Stevens, NE;van Wolfswinkel, M;Bao, W;Ryan, FJ;Brook, B;Amenyogbe, N;Marshall, HS;Lynn, MA;Kollmann, TR;Tumes, DJ;Lynn, DJ;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Nature Chemical Biology
Weiss, RJ;Spahn, PN;Chiang, AWT;Liu, Q;Li, J;Hamill, KM;Rother, S;Clausen, TM;Hoeksema, MA;Timm, BM;Godula, K;Glass, CK;Tor, Y;Gordts, PLSM;Lewis, NE;Esko, JD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell
Zhang, S;Edwards, TN;Chaudhri, VK;Wu, J;Cohen, JA;Hirai, T;Rittenhouse, N;Schmitz, EG;Zhou, PY;McNeil, BD;Yang, Y;Koerber, HR;Sumpter, TL;Poholek, AC;Davis, BM;Albers, KM;Singh, H;Kaplan, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, MY;Dean, ED;Quittner-Strom, E;Zhu, Y;Chowdhury, KH;Zhang, Z;Zhao, S;Li, N;Ye, R;Lee, Y;Zhang, Y;Chen, S;Yu, X;Leonard, DC;Poffenberger, G;Von Deylen, A;McCorkle, SK;Schlegel, A;Sloop, KW;Efanov, AM;Gimeno, RE;Scherer, PE;Powers, AC;Unger, RH;Holland, WL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Diagnostic Microbiology And Infectious Disease
Scobie, H;Khetsuriani, N;Efstratiou, A;Priest, J;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Vaccine
McAlister, SM;van den Biggelaar, AHJ;Woodman, TL;Hutton, H;Thornton, RB;Richmond, PC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Research Square
Rudensky, A;Hu, W;Wang, Z;Feng, Y;Schizas, M;Hoyos, B;Veeken, J;Verter, J;Puerto, R;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Biorxiv
Hu, M;Golovchenko, N;Kelly, T;Agos, J;Zeglinski, M;Bonder, E;Sandrock, I;Prinz, I;Granville, D;Watson, A;Edelblum, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Biologicals : Journal Of The International Association Of Biological Standardization
Riches-Duit, R;Hassall, L;Kogelman, A;Westdijk, J;Dobly, A;Francotte, A;Stickings, P;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Dikiy, S;Li, J;Bai, L;Jiang, M;Janke, L;Zong, X;Hao, X;Hoyos, B;Wang, ZM;Xu, B;Fan, Y;Rudensky, AY;Feng, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Reports
Clark, NM;Martinez, LM;Murdock, S;deLigio, JT;Olex, AL;Effi, C;Dozmorov, MG;Bos, PD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
JCI Insight
Xiong, Y;Zhong, Q;Palmer, T;Benner, A;Wang, L;Suresh, K;Damico, R;D'Alessio, FR;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Scientific Reports
Lee, S;Song, JJ;Beyer, LA;Swiderski, DL;Prieskorn, DM;Acar, M;Jen, HI;Groves, AK;Raphael, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Neuroscience
Lee, S;Kurioka, T;Lee, MY;Beyer, LA;Swiderski, DL;Ritter, KE;Raphael, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal Of Clinical Investigation
Li, W;Gauthier, JM;Tong, AY;Terada, Y;Higashikubo, R;Frye, CC;Harrison, MS;Hashimoto, K;Bery, AI;Ritter, JH;Nava, RG;Puri, V;Wong, BW;Lavine, KJ;Bharat, A;Krupnick, AS;Gelman, AE;Kreisel, D;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cellular And Molecular Gastroenterology And Hepatology
Fu, N;Wu, F;Jiang, Z;Kim, W;Ruan, T;Malagola, E;Ochiai, Y;Nápoles, OC;Valenti, G;White, RA;Belin, BR;Zamechek, LB;LaBella, JS;Wang, TC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Reports
Escalante, A;Klein, R;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Brain Sciences
Shi, Z;Bamford, IJ;McKinley, JW;Devi, SPS;Vahedipour, A;Bamford, NS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Neuron
Gatto, G;Bourane, S;Ren, X;Di Costanzo, S;Fenton, PK;Halder, P;Seal, RP;Goulding, MD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Reports
Wan, Y;Feng, B;You, Y;Yu, J;Xu, C;Dai, H;Trapp, BD;Shi, P;Chen, Z;Hu, W;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Metabolism
Miletta, MC;Iyilikci, O;Shanabrough, M;estan-Pea, M;Cammisa, A;Zeiss, CJ;Dietrich, MO;Horvath, TL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Communications
Chen, S;Gao, XF;Zhou, Y;Liu, BL;Liu, XY;Zhang, Y;Barry, DM;Liu, K;Jiao, Y;Bardoni, R;Yu, W;Chen, ZF;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Metabolism
Zou, W;Rohatgi, N;Brestoff, JR;Li, Y;Barve, RA;Tycksen, E;Kim, Y;Silva, MJ;Teitelbaum, SL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Communications
Zhou, M;Sacirbegovic, F;Zhao, K;Rosenberger, S;Shlomchik, WD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Immunology
Inclan-Rico, JM;Ponessa, JJ;Valero-Pacheco, N;Hernandez, CM;Sy, CB;Lemenze, AD;Beaulieu, AM;Siracusa, MC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Frontiers In Immunology
Johnson, B;McAlister, S;McGuire, H;Palanivelu, V;Stevenson, A;Richmond, P;Palmer, D;Metcalfe, J;Prescott, S;Wood, F;Fazekas de St Groth, B;Linden, M;Fear, M;Fear, V;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Proceedings Of The National Academy Of Sciences Of The United States Of America
Antonelli, AC;Binyamin, A;Hohl, TM;Glickman, MS;Redelman-Sidi, G;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Medicine
Koelwyn, GJ;Newman, AAC;Afonso, MS;van Solingen, C;Corr, EM;Brown, EJ;Albers, KB;Yamaguchi, N;Narke, D;Schlegel, M;Sharma, M;Shanley, LC;Barrett, TJ;Rahman, K;Mezzano, V;Fisher, EA;Park, DS;Newman, JD;Quail, DF;Nelson, ER;Caan, BJ;Jones, LW;Moore, KJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Apoptosis : An International Journal On Programmed Cell Death
Aravani, D;Foote, K;Figg, N;Finigan, A;Uryga, A;Clarke, M;Bennett, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature
Zhou, T;Damsky, W;Weizman, OE;McGeary, MK;Hartmann, KP;Rosen, CE;Fischer, S;Jackson, R;Flavell, RA;Wang, J;Sanmamed, MF;Bosenberg, MW;Ring, AM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Medical Journal of Chinese People's Liberation Army
Xin, YW;Dong, N;Yao, WU;Chai, YF;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
American Journal Of Respiratory Cell And Molecular Biology
Mock, JR;Dial, CF;Tune, MK;Gilmore, RC;O'Neal, WK;Dang, H;Doerschuk, CM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Biorxiv
Morales-Nebreda, L;Helmin, K;Markov, N;Piseaux, R;Acosta, M;Abdala-Valencia, H;Politanska, Y;Singer, B;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Research Square
Haraguchi, A;Yamada, H;Sakuragi, T;Tsuru, T;Kondo, M;Nakashima, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Leukemia
Ozono, Y;Shide, K;Kameda, T;Kamiunten, A;Tahira, Y;Sekine, M;Akizuki, K;Nakamura, K;Iwakiri, H;Sueta, M;Hidaka, T;Kubuki, Y;Yamamoto, S;Hasuike, S;Sawaguchi, A;Nagata, K;Shimoda, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Vaccine
Breakwell, L;Anga, J;Cooley, G;Ropiti, L;Gwyn, S;Wannemuehler, K;Woodring, J;Ogaoga, D;Martin, D;Patel, M;Tohme, RA;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Cell Host & Microbe
Guo, Y;Kasahara, S;Jhingran, A;Tosini, NL;Zhai, B;Aufiero, MA;Mills, KAM;Gjonbalaj, M;Espinosa, V;Rivera, A;Luster, AD;Hohl, TM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Plos Pathogens
Tischler, BY;Tosini, NL;Cramer, RA;Hohl, TM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Scientific Reports
Wenzel, EV;Bosnak, M;Tierney, R;Schubert, M;Brown, J;Dbel, S;Efstratiou, A;Sesardic, D;Stickings, P;Hust, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin CRM197, Mutant
Biorxiv
Edwards, T;Zhang, S;Liu, A;Cohen, J;Zhou, P;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Biorxiv
da Silva Antunes, R;Pomaznoy, M;Soldevila, F;Babor, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Research Square
Xu, P;Liu, Z;Liu, Y;Ma, H;Xu, Y;Bao, Y;Zhu, S;Cao, Z;Zhou, Z;Wei, W;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The American Journal Of Tropical Medicine And Hygiene
Njenga, SM;Kanyi, HM;Arnold, BF;Matendechero, SH;Onsongo, JK;Won, KY;Priest, JW;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Clinical Science
Krishna, SM;Moran, CS;Jose, RJ;Lazzaroni, S;Huynh, P;Golledge, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Hearing Research
Hicks, KL;Wisner, SR;Cox, BC;Stone, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal Of Immunological Methods
Moreno, I;Domnguez, M;Torao, A;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
European Journal Of Immunology
Zhang, Z;Legoux, FP;Vaughan, SW;Moon, JJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Neuron
Paixo, S;Loschek, L;Gaitanos, L;Alcal Morales, P;Goulding, M;Klein, R;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Blood
Mende, N;Jolly, A;Percin, GI;Gnther, M;Rostovskaya, M;Krishnan, SM;Oostendorp, RAJ;Dahl, A;Anastassiadis, K;Hfer, T;Waskow, C;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal Of Allergy And Clinical Immunology
Allard, B;Panariti, A;Pernet, E;Downey, J;Ano, S;Dembele, M;Nakada, E;Fujii, U;McGovern, TK;Powell, WS;Divangahi, M;Martin, JG;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell
Cohen, JA;Edwards, TN;Liu, AW;Hirai, T;Jones, MR;Wu, J;Li, Y;Zhang, S;Ho, J;Davis, BM;Albers, KM;Kaplan, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Neuron
McKinley, JW;Shi, Z;Kawikova, I;Hur, M;Bamford, IJ;Sudarsana Devi, SP;Vahedipour, A;Darvas, M;Bamford, NS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Reports
Acton, D;Ren, X;Di Costanzo, S;Dalet, A;Bourane, S;Bertocchi, I;Eva, C;Goulding, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Transplant International : Official Journal Of The European Society For Organ Transplantation
Christiansen, D;Mouhtouris, E;Hodgson, R;Sutton, VR;Trapani, JA;Ierino, FL;Sandrin, MS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal Of Biological Chemistry
Burress, H;Kellner, A;Guyette, J;Tatulian, SA;Teter, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature
Croft, AP;Campos, J;Jansen, K;Turner, JD;Marshall, J;Attar, M;Savary, L;Wehmeyer, C;Naylor, AJ;Kemble, S;Begum, J;Drholz, K;Perlman, H;Barone, F;McGettrick, HM;Fearon, DT;Wei, K;Raychaudhuri, S;Korsunsky, I;Brenner, MB;Coles, M;Sansom, SN;Filer, A;Buckl
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Biorxiv
Njenga, SM;Kanyi, HM;Arnold, BF;Matendechero, HS;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Cell
Binnewies, M;Mujal, AM;Pollack, JL;Combes, AJ;Hardison, EA;Barry, KC;Tsui, J;Ruhland, MK;Kersten, K;Abushawish, MA;Spasic, M;Giurintano, JP;Chan, V;Daud, AI;Ha, P;Ye, CJ;Roberts, EW;Krummel, MF;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Plos Pathogens
Heung, LJ;Hohl, TM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Scientific Reports
Yang, W;Zhao, X;Tao, Y;Wu, Y;He, F;Tang, L;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Development
McGovern, MM;Randle, MR;Cuppini, CL;Graves, KA;Cox, BC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
JCI Insight
Mock, JR;Dial, CF;Tune, MK;Norton, DL;Martin, JR;Gomez, JC;Hagan, RS;Dang, H;Doerschuk, CM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Scientific Reports
Morhardt, TL;Hayashi, A;Ochi, T;Quirs, M;Kitamoto, S;Nagao-Kitamoto, H;Kuffa, P;Atarashi, K;Honda, K;Kao, JY;Nusrat, A;Kamada, N;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal Of Immunology
Yeo, KT;Embury, P;Anderson, T;Mungai, P;Malhotra, I;King, C;Kazura, J;Dent, A;
Product: Diphtheria Toxin CRM197, Mutant
Hearing Research
Hirose, K;Li, SZ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Communications
Cavalcanti-de-Albuquerque, JP;Bober, J;Zimmer, MR;Dietrich, MO;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
October 17, 2019
By: List Labs
List Labs currently has over 3300 citations with more being added every month! Within our citations page, we provide the ability to search and sort from over 100 cataloged items that are offered here. We are honored to supply researchers worldwide with highly purified bacterial toxins that can potentially be instrumental in helping to change […]
July 23, 2018
By: douano@listlabs.com
By: Mary N. Wessling, Ph.D. ELS In this blog we will unravel the terminology describing bacterial toxins. In general, there are at least three ways that bacterial toxins are described in the literature: by their biological designation—the genus and/or species from which they come by the origin of the toxin, either as innate to the […]
March 19, 2018
By: douano@listlabs.com
By: Mary N. Wessling, Ph.D. ELS List Biological Laboratories’ (List Labs) catalog of products is related to furthering research in human health and preventing disease, most commonly as the starting materials for vaccine research & development or production around the world. Vaccines are mainly identified for their capacity to prevent diseases that the body’s innate defensive […]
January 8, 2018
By: douano@listlabs.com
By: Rachel Berlin, Marketing Manager The List Labs website hosts a library of scientific article abstracts related to the research performed using our products called the Citations Page. Visitors can search this library to learn how others have used List Labs’ reagents in their research. This valuable resource is updated monthly with new articles from a wide variety […]
March 27, 2017
By: douano@listlabs.com
By: Mary N. Wessling, Ph.D. ELS Cross-Reacting Materials: The Motor Behind Conjugate Vaccines Vaccines in history The history and practice of vaccination as protection against viral infection is often thought to begin with Edward Jenner’s discovery that cowpox, a viral infection of cows, prevented smallpox in humans. However, it had long been suspected that survivors […]
December 12, 2016
By: List Labs
By: Suzanne Canada, Ph.D. Diphtheria toxin is an important tool used for selective killing (ablation) of cells for research purposes. Using this technique, dubbed “toxin receptor–mediated cell knockout” when it was first used [1], researchers can selectively remove a specific type of cell in a live mouse without having to generate transgenic “knockout” animals, which […]
August 15, 2016
By: douano@listlabs.com
By: Md. Elias, Ph.D, Senior Scientist List Labs is one of the leading manufacturers of high quality adjuvants from bacterial sources. Our highly purified adjuvants for research and development are Tetanus Toxoid (Product #191), Cholera Toxin B Subunit (Product #104), Diphtheria Toxin CRM197 Mutant (Product #149), Adenylate Cyclase Mutant, Cya-AC– (Product #198L), Pertusis Toxin Mutant (Product #184), […]
April 25, 2016
By: douano@listlabs.com
By: Karen Crawford, Ph.D., President In 1983, List Labs introduced Diphtheria Toxin to the research community. Researchers have purchased Diphtheria Toxin for various uses. One common use is cell ablation. The receptor for Diphtheria Toxin is also called heparin-binding EGF-like growth factor (HB-EGF). This receptor, located on several cell types, binds Diphtheria Toxin, allowing the toxin to enter […]
April 6, 2015
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing Concerns over outbreaks of potentially serious childhood diseases are in the news again in California with an increase in whooping cough infections in 2014, caused by the pathogen Bordetella pertussis, and a measles outbreak in December 2014 to February 2015. Since outbreaks and epidemics may be infrequent, many […]
January 26, 2015
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing An exciting report was released in October about a new class of targeted anti-tumor drugs, in which genetically engineered stem cells were used to deliver cytotoxins to brain tumors.1 Brain cancers known as glioblastomas (GBM) are notoriously difficult to treat because the tumors often re-grow after surgery and because […]
October 21, 2014
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing Vaccines have been used to help control diseases for more than 200 years and are the common practice for children and adults. Childhood vaccination has substantially reduced the morbidity and mortality from infectious diseases in much of the developed world, and influenza vaccinations have reduced the impact […]
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